Publications by authors named "A I Kosmin"
Article Synopsis
- - Hypermobile Ehlers-Danlos syndrome (hEDS) is a common inherited disorder affecting connective tissues, leading to challenges in diagnosing due to symptom overlaps and limited healthcare provider knowledge, resulting in lengthy and costly diagnostic journeys for patients
- - The study aimed to evaluate a prototype diagnostic tool for hEDS that can help patients communicate their symptoms more effectively to clinicians, potentially improving diagnosis and overall patient experiences
- - Participants provided feedback on the tool through questionnaires and focus groups, and their experiences were assessed using the Mobile App Rating Scale (MARS) to evaluate aspects like engagement, functionality, aesthetics, and information quality
Article Synopsis
- PD-L1 testing, crucial for understanding cancer treatment responses, is typically done via immunohistochemistry (IHC), but this study explores how PCR-based measurements of PD-L1 RNA compare with IHC results across different commercial assays.
- In a study of 167 non-squamous non-small cell lung carcinomas, there was moderate correlation between RNA and protein expression, and PCR testing revealed that most tumors classified as PD-L1-low by RNA did not show PD-L1 protein presence according to IHC.
- The findings suggest that while some tumors have high RNA levels of PD-L1, they may not meet IHC cut-offs, indicating the need for further research into whether these differences are due to technical issues or biological
Unlabelled: JAK-inhibitors are small molecules blocking the JAK-STAT pathway that have proven effective in the treatment of different immune-mediated diseases in adults and juvenile idiopathic arthritis (JIA).
Aim Of Study: To evaluate the safety and efficacy of tofacitinib in children with different rheumatic diseases.
Material And Methods: We extracted information from 24 children with the following diagnosis: JIA ( = 15), undifferentiated systemic autoinflammatory diseases (SAIDs) ( = 7), and juvenile dermatomyositis (JDM) ( = 2) who have been treated with tofacitinib for a period of longer than 6 months.
Introduction: Spontaneous bacterial peritonitis can be differentiated from secondary bacterial peritonitis by the absence of a surgically treatable intra-abdominal source of infection. However, oftentimes this is unapparent and other clinical clues need to be sought after to make the right diagnosis.
Case: A 64-year-old woman was admitted because of three days of worsening diffuse abdominal pain and distention.