Performance-Based Design of Ferronickel Slag Alkali-Activated Concrete for High Thermal Load Applications.

This study aimed to develop optimized alkali-activated concrete using ferronickel slag for high-temperature applications, focusing on minimizing environmental impact while maintaining high compressive strength and slump. A response surface methodology, specifically the mixture design of experiments, was employed to optimize five components: water, FNS-based alkali-activated binder, and three aggregate sizes. Twenty concrete mixes were tested for slump and compressive strength before and after exposure to 600 °C for two hours.

Optimal Design of Ferronickel Slag Alkali-Activated Material for High Thermal Load Applications Developed by Design of Experiment.

The development of an optimal low-calcium alkali-activated binder for high-temperature stability based on ferronickel slag, silica fume, potassium hydroxide, and potassium silicate was investigated based on Mixture Design of Experiment (Mixture DOE). Mass loss, shrinkage/expansion, and compressive and flexural strengths before and after exposure to a high thermal load (900 °C for two hours) were selected as performance markers. Chemical activator minimization was considered in the selection of the optimal mix to reduce CO emissions.

Narcolepsy treatment in Sweden: An observational study.

Objectives: To describe the pharmacological treatments (2005-2017) and the healthcare utilization (1997-2016) for patients with narcolepsy in Sweden in order to create a framework for future organizational and economic analyses.

Material & Methods: Patients of all ages with a diagnosis of narcolepsy registered in the National Patient Registry in specialist care in Sweden were included and information on treatments for narcolepsy was retrieved from The Swedish Prescribed Drug Register.

Results: We collected 2508 patients with narcolepsy, 43,3% men and 56,7% women and 47,9% were prescribed modafenil, 33,8% metylphenidate and 26,2% amphetamine.

VASA-induced cytoplasmic localization of CYTB-positive mitochondrial substance occurs by destructive and nondestructive mitochondrial effusion, respectively, in early and late spermatogenic cells of the Manila clam.

To analyze the release of mitochondrial material, a process that is believed to be (i) induced by the VASA protein derived from germplasm granules, and (ii) which appears to play an important role during meiotic differentiation, the localization of the CYTB protein was studied in the process of spermatogenesis of the bivalve mollusk Ruditapes philippinarum (Manila clam). It was found that in early spermatogenic cells, such as spermatogonia and spermatocytes, the CYTB protein shows dispersion in the cytoplasm following the total disaggregation of VASA-invaded mitochondria, what is called here as "destructive mitochondrial effusion (DME)." It was found that the mitochondria of the maturing sperm cells also uptake VASA.

Germ plasm-related structures in marine medaka gametogenesis; novel sites of Vasa localization and the unique mechanism of germ plasm granule arising.

Germ plasm, a cytoplasmic factor of germline cell differentiation, is suggested to be a perspective tool for in vitro meiotic differentiation. To discriminate between the: (1) germ plasm-related structures (GPRS) involved in meiosis triggering; and (2) GPRS involved in the germ plasm storage phase, we investigated gametogenesis in the marine medaka Oryzias melastigma. The GPRS of the mitosis-to-meiosis period are similar in males and females.