[Occupational risk during chemical exposure].

Methods for assessing the occupational risk were tested in chemically exposed workers at some enterprises by taking into account a priori and a posteriori components. The risk values were calculated by the indices of collective and individual health, which were used to develop conceptual models for the assessment and management of risks, whose efficiency may be evaluated. A package of measures has been worked out to reduce human health occupational risks.

[Disorders of antioxidant defence and their correction in experimental di-isopropyl-phenyl-isocyanate intoxication].

Using preventively natural and artificial antioxidants in experiments on white rats enabled to assess role of lipids peroxidation in mechanisms of acute inhalation toxicity caused by 2,6-diisopropylphenylisocyanate. Correlation and regression analysis revealed differences in mechanisms underlying antioxidants effects.

[Prospects of the development of preventive toxicology in the 21st century].

The national toxicology has created considerable theoretical potential to enter XXI century. Significant experience is associated with introducing the novelties. However, some circumstances inhibit environmental protection from chemical disorder.

[The toxicological, hygienic and clinical aspects of the action of low levels of organic solvents].

The article presents experimental data showing that Average Shift Concentration (ASC) and Maximal Single Concentration (MSC) for some solvents (tetrachloromethane, tetrachloroethane, dimethylformamide, benzene) are expedient to be justified. Clinical and hygienic materials proved significant health parameters (nervous system, peripheral blood) and urine levels of main metabolites to depend on chlorbenzene and toluene concentrations influencing the workers. Having analyzed the results, the authors recommended following hygienic norms in the air of workplace: for chlorbenzene ASC--50 mg/cu m, MSC--100 mg/cu m; biologic MAC for urine 4-chlorcatechol--0.

[Hygienic aspects of the regulation of occupational chemicals].

Hygienic regulation of chemical hazards in the air of workplace has a 70-year history in this country. Now a definition "maximal allowable concentration in the air of workplace" needs to be more precise, and a list of MACs should be modified.