Publications by authors named "A I Kalganova"
Despite the achievements brought about by high-throughput screening technologies, there is still a lack of effective platforms to be used to search for new antimicrobial drugs. The antimicrobial activity of compounds continues, for the most part, to be assessed mainly using pathogen cultures, a situation which does not make easy a detailed investigation of the molecular mechanisms underlying host-pathogen interactions. testing of promising compounds using chordate models is labor-intensive and expensive and, therefore, is used in preclinical studies of selected drug candidates but not in primary screening.
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- - Innate immunity in invertebrates provides effective antimicrobial peptides (AMPs) that combat drug-resistant infections, sparking interest in finding new β-hairpin AMPs from worm proteins with a BRICHOS domain.
- - Researchers discovered new BRICHOS AMPs from caecilians, a lesser-known group of vertebrates, revealing similarities to lung surfactants and suggesting a unique lung function.
- - The identified peptides show strong antibacterial properties against multidrug-resistant ESKAPE pathogens while being low in toxicity, indicating potential as a new antibiotic model and highlighting a previously unrecognized lung immunity mechanism.