Publications by authors named "A I Isaev"
Using BW25113 as a host, we isolated a novel lytic phage from the commercial poly-specific therapeutic phage cocktail Sextaphage (Microgen, Russia). We provide genetic and phenotypic characterization of the phage and describe its host range on the ECOR collection of reference strains. The phage, hereafter named Sxt1, is a close relative of classical coliphage T3 and belongs to the genus, yet its internal virion proteins, forming an ejectosome, differ from those of T3.
View Article and Find Full Text PDFSecreted and membrane-tethered mammalian neuromodulators from the Ly6/uPAR family are involved in regulation of many physiological processes. Some of them are expressed in the CNS in the neurons of different brain regions and target neuronal membrane receptors. Thus, Lynx1 potentiates nicotinic acetylcholine receptors (nAChRs) in the brain, while others like Lypd6 and Lypd6b suppress it.
View Article and Find Full Text PDFArticle Synopsis
- Population allele frequency is essential for understanding genetic variants in medicine, and large databases like gnomAD serve as references.
- Variances in rare allele frequencies between populations suggest that local data can be more informative than global averages; many regions, including Russia, lack comprehensive genetic studies.
- The RUSeq project created a large genetic variant reference set from 7,452 exome samples in Moscow and St. Petersburg, revealing significant genetic diversity and identifying notable pathogenic variants specific to Russia.
Comparative Analysis of the Neutralizing Capacity of Monovalent and Bivalent Formulations of Betuvax-CoV-2, a Subunit Recombinant COVID-19 Vaccine, Against Various Strains of SARS-CoV-2.
Vaccines (Basel)
October 2024
Article Synopsis
- - SARS-CoV-2, responsible for COVID-19, is rapidly evolving, making the development of effective and safe vaccines critical for public health, with the Betuvax-CoV-2 vaccine showing promise in previous trials.
- - A study compared monovalent and bivalent vaccines' ability to neutralize different SARS-CoV-2 strains, revealing that while both types had strengths against certain variants, neither performed well against the Omicron BQ.1 strain at lower doses.
- - The research implies that vaccine effectiveness relies on matching the formulation to the circulating SARS-CoV-2 strain, and using a bivalent vaccine doesn't necessarily provide an advantage over a monovalent vaccine for a single variant.