Elevated p16Ink4a Expression Enhances Tau Phosphorylation in Neurons Differentiated From Human-Induced Pluripotent Stem Cells.

Increased expression of the cyclin-dependent kinase inhibitor p16Ink4a (p16) is detected in neurons of human Alzheimer's disease (AD) brains and during normal aging. Importantly, selective eliminating p16-expressing cells in AD mouse models attenuates tau pathologies and improves cognition. But whether and how p16 contributes to AD pathogenesis remains unclear.

Automated derivation of diagnostic criteria for lung cancer using natural language processing on electronic health records: a pilot study.

Background: The digitisation of healthcare records has generated vast amounts of unstructured data, presenting opportunities for improvements in disease diagnosis when clinical coding falls short, such as in the recording of patient symptoms. This study presents an approach using natural language processing to extract clinical concepts from free-text which are used to automatically form diagnostic criteria for lung cancer from unstructured secondary-care data.

Methods: Patients aged 40 and above who underwent a chest x-ray (CXR) between 2016 and 2022 were included.

Spontaneous flows and quantum analogies in heterogeneous active nematic films.

Incorporating the inherent heterogeneity of living systems into models of active nematics is essential to provide a more realistic description of biological processes such as bacterial growth, cell dynamics and tissue development. Spontaneous flow of a confined active nematic is a fundamental feature of these systems, in which the role of heterogeneity has not yet been considered. We therefore determine the form of spontaneous flow transition for an active nematic film with heterogeneous activity, identifying a correspondence between the unstable director modes and solutions to Schrödinger's equation.

Ethnicity and Socioeconomic Disparities in Clinical Trial Participation for Ovarian Cancer: A Retrospective Observational Study in London.

Background: Ethnic and socioeconomic disparities in cancer outcomes are exacerbated by clinical trial underrepresentation. This study aims to identify inequalities in ethnicity and socioeconomic features among ovarian cancer clinical trial participants in two London cancer centres.

Methods: All ovarian cancer patients treated between 2017 and 2022 were included.

Additionality in Blue Carbon Ecosystems: Recommendations for a Universally Applicable Accounting Methodology.

Blue carbon ecosystems (BCEs) remove carbon dioxide from the atmosphere and store significant amounts of organic carbon (OC) in their soils. Consequently, the protection and restoration of BCEs may contribute to net greenhouse gas emissions abatement and help address the global challenges of both mitigating and adapting to climate change. An ongoing debate is whether OC sequestered out with the blue carbon (BC) project and transported to its present location (allochthonous) should be counted as 'additional'.