Publications by authors named "A I Fedorov"
Anti-cancer targeted therapy is a promising approach. However, the identification of target molecules over-expressed in a wide range of tumors remains a significant challenge. The aim of this study was to analyze the expression of cell membrane-exposed heat shock protein 70 kDa (mHSP70) on different tumor cells and to develop a nanoscale delivery system based on a monoclonal antibody (mAb) that recognizes mHSP70 and uses chitosan core-shell nanoparticles (NPs).
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- Acute appendicitis is a common surgical emergency where an inflamed appendix leads to abdominal pain, typically in the lower right quadrant.
- Diagnosis involves a combination of patient history, physical examination, and imaging tests like ultrasound or CT scans.
- Treatment usually requires an appendectomy, either laparoscopic or open surgery, and timely intervention can prevent complications like perforation.
Article Synopsis
- Alzheimer's disease was experimentally induced in female Wistar rats through injections of β-amyloid into the hippocampus.
- Following this, olfactory mucosa cells were transplanted into the same brain region and showed survival and clustering by week 4.
- The transplanted cells improved cognitive functions significantly between weeks 3-5, suggesting potential for further research on these cells as a personalized treatment for Alzheimer's disease.
Article Synopsis
- Urethral diverticulum is a rare condition causing a sac-shaped bulge in the urethra, often seen in urology.
- The article discusses a clinical case involving conservative management during pregnancy and a surgical procedure after childbirth.
- It emphasizes that pregnant women with this condition should be treated conservatively and highlights the need for better training for medical professionals regarding this rare disease.