[Effect of succinate-containing medications on hepatic structural changes in acute experimental cholecystitis].

Histological and electron microscopic changes in the hepatic structure were studied in animals with acute experimental cholecystitis. The administration of the succinate-containing drugs reamberin and mexidole decreased the magnitude of morphological changes in the liver tissue. Morphometric examination revealed that reamberin versus mexidole showed a high efficacy in reducing the area of hepatocytic necrosis.

[Variants of the anatomical structure of frontal sinuses based on the results of X-ray computed tomography].

The objective of the present work was to analyse computed tomograms of brain and paranasal sinuses obtained from 3,054 patients with a view to elucidating specific features of the latter's structure. The following structural variants were distinguished: agenesia, hypogenesia, and hypergenesia. Orbital, zygomatic, temporal, cock's comb, ethmoidal, and nasal recesses in the frontal sinuses were described.

[Demographic aspects of social security of elderly population in the Barents Euro-Arctic Region].

Social security of elderly people is discussed at different levels of the realization of the geronto-social policy in the Barents Euro-Arctic Region within the context of the Madrid Plan of Actions on Aging. There have been comparatively analyzed demographic indicators that show age structures of the regions which are parts of the Barents Euro-Arctic Region. There have been defined regional differences and trends of improvement of geronto-social policy for providing security of life activity of elderly people in the Russian part of the Barents Euro-Arctic Region.

[Changes of the neuropil ultrastructure in the CA1 hippocampal area of rat pups after hyaluronidase treatment].

Electron microscopical and electrophysiological studies were carried out in cross-sections of the hippocampus of 4-weeks-old male rat pups (n = 35) to detect the ultrastructural changes in CA1 hippocampal area and the peculiarities of excitatory postsynaptic potential formation in this brain area after the incubation of the sections in the solution of hyaluronidase (10 U/ml), the enzyme which specifically degrades the extracellular matrix glycosaminoglycan--the hyaluronic acid. The reduction of the width of synaptic cleft by 15-25% in the axo-dendritic contacts of the stratum radiatum of CA1 hippocampal area was detected 1.5 min following the application of enzyme, coinciding with the increase of the excitatory postsynaptic potential amplitude.

[SRE, NF-kappaB, and AP-1 DNA-binding activities induced by A431 cell adhesion correlate with actin cytoskeleton reorganization].

Cell adhesion to extracellular matrix proteins induces activation of different signal molecules and influences gene expression. As shown earlier, epidermoid carcinoma A431 cell adhesion to fibronectin, laminin-2/4 or antibodies to receptor EGF (ab EGFR) results in reorganization of specific cell shape and actin cytoskeleton in the majority of cells. This study resolves a question whether morphological changes are accompanied with some cell response at the level of gene expression in nuclei.