Regulation of lipid peroxidation in the retina under the effect of bright light.

Changes in LPO intensity under the effect of exposure to bright light and the possibility of their correction with antioxidants were studied on rabbits with diabetic retinopathy. It was found that enhanced LPO caused by exposure to bright light in rabbits with diabetic retinopathy can be corrected with antioxidants. Phenosan potassium salt, α-tocopherol, and oxypyridine were more effective than SOD and taurine in preventing MDA accumulation.

Use of natural antioxidants for the correction of changes in general and local parameters of lipid peroxidation and antioxidant defense system during experimental eye burn.

The effect of natural antioxidants in grade III chemical eye burn was studied in experiments on rabbits at various stages of burn disease. The use of histochrome, Gingko Biloba, and diquertin in combination with complex drug therapy decelerated the decrease in the antioxidant potential of tear fluid and blood plasma. This treatment was also followed by a decrease in the concentration of end products of free radical oxidation.

Antioxidant potential of tear fluid and blood plasma in rabbits with grade III chemical eye burn at various stages of burn disease.

The antioxidant potential of tear fluid and plasma in rabbits with chemical eye burn of grade III was measured at various stages of burn disease. Eye burns were accompanied by depletion of the antioxidant system in tear fluid and plasma and impairment of antioxidant defense in the whole organism. These changes contribute to activation of free radical lipid peroxidation.

[Features of lipid peroxidation in the vitreous body and retina during intravitreal hemorrhaging in dithiosone-induced diabetes].

It has been stated that in experimental dithiazone-induced diabetes lipid peroxidation is intensified in vitreous body and retina of the rabbits' eyes. The increase of LP in vitreous body and retina during intravitreal hemorrhage due to experimental diabetes was controlled by antioxidants.

[The role of melanin in regulating free radical processes in the epithelial eye pigment in acute hypoxia].

Retinal response to the acute hypoxia and reoxygenation were shown to be independent of melanin presence in the eye pigmental epithelium (PE), i.e. in the retinas of both pigmented animals and albinos hypoxia survived an increase in the content of hydroperoxidases and malonyl dialdehyde; subsequent reoxygenation resulted in a more considerable accumulation of lipid peroxidation (LPO) products in both retinal types.