Publications by authors named "A I Doronin"
Article Synopsis
- - Prolgolimab is an improved anti-PD-1 antibody that shows strong efficacy in treating metastatic melanoma and features a modified LALA mutation.
- - Comparative studies indicate that prolgolimab has higher PD-1 receptor occupancy and T-cell activation than conventional antibodies like nivolumab and pembrolizumab, while showing less activation of antibody-dependent cellular phagocytosis.
- - In mouse studies, prolgolimab inhibited tumor growth by 56%, significantly outperforming pembrolizumab's 16% inhibition, suggesting a need for clinical comparisons between IgG1 and IgG4 anti-PD-1 antibodies.
We explore the propagation of structured vortex laser beams-shaped light carrying orbital angular momentum (OAM)-through complex multiple scattering medium. These structured vortex beams consist of a spin component, determined by the polarization of electromagnetic fields, and an orbital component, arising from their spatial structure. Although both spin and orbital angular momenta are conserved when shaped light propagates through a homogeneous, low-scattering medium, we investigate the conservation of these angular momenta during the propagation of Laguerre-Gaussian (LG) beams with varying topological charges through a turbid multiple scattering environment.
View Article and Find Full Text PDFThis study introduces a novel approach in the realm of liquid biopsies, employing a 3D Mueller-matrix (MM) image reconstruction technique to analyze dehydrated blood smear polycrystalline structures. Our research centers on exploiting the unique optical anisotropy properties of blood proteins, which undergo structural alterations at the quaternary and tertiary levels in the early stages of diseases such as cancer. These alterations manifest as distinct patterns in the polycrystalline microstructure of dried blood droplets, offering a minimally invasive yet highly effective method for early disease detection.
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