Publications by authors named "A I Dell"
Protein glycosylation has been considered as a fundamental phenomenon shared by all domains of life. In , glycosylation of flagellins A and B with pseudaminic acid have been rigorously confirmed and shown to be essential for flagella assembly and bacterial colonization. In addition to flagellins, several other proteins including RecA, AlpA/B, and BabA/B in have also been reported to be glycosylated and to be dependent on the lipopolysaccharide (LPS) biosynthetic pathway.
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- Klebsiella pneumoniae is an opportunistic pathogen that poses significant health risks, and its treatment is complicated by the emergence of multidrug-resistant strains.
- Bacteriophages that target K. pneumoniae produce specialized enzymes called depolymerases, which can break down the bacteria's protective capsules, making them potential new antimicrobials.
- Understanding the structures and mechanisms of these depolymerases is crucial for developing effective therapies, as they show diversity in their function and specificity, suggesting potential for engineering improved enzymes for treatment.
Article Synopsis
- * An analysis of 302 pregnant women revealed that non-secretors with certain types of bacterial diversity had shorter gestational periods, particularly in those with depleted bacterial types early in pregnancy.
- * The findings suggest that secretor status and the expression of blood-group antigens play a crucial role in the interaction between vaginal microbiota and pregnancy outcomes, especially regarding preterm birth risks.
In ectotherms, the performance of physiological, ecological and life-history traits universally increases with temperature to a maximum before decreasing again. Identifying the most appropriate thermal performance model for a specific trait type has broad applications, from metabolic modelling at the cellular level to forecasting the effects of climate change on population, ecosystem and disease transmission dynamics. To date, numerous mathematical models have been designed, but a thorough comparison among them is lacking.
View Article and Find Full Text PDFDiversity increases toward the tropics, but the strength of this pattern diverges with thermoregulatory strategy. Synthesizing over 30,000 species distributions, we quantified patterns of richness in terrestrial vertebrates, and present evidence for a latitudinal gradient of community composition. We observe a two orders of magnitude shift in comparative diversity with temperature, from endothermic mammal and avian dominance near the poles, toward ectothermic reptile and amphibian majority in the tropics.
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