Single-molecule fluorescence spectroscopy offers unique capabilities for the low-concentration sensing and probing of molecular dynmics. However, employing such a methodology for versatile sensing and diagnostics under point-of-care demands device miniaturization to lab-on-a-chip size. In this study, we numerically design metalenses with high numerical aperture (NA = 1.
View Article and Find Full Text PDFWe demonstrate optical nonthermal excitation of exchange dominated spin waves of different orders in a magnetophotonic crystal. The magnetophotonic structure consists of a thin magnetic film and a Bragg stack of nonmagnetic layers to provide a proper nonuniform interference pattern of the inverse Faraday effect induced by light in the magnetic layer. We found a phenomenon of the pronounced phase slippage of the inverse Faraday effect distribution when the pump wavelength is within the photonic band gap of the structure.
View Article and Find Full Text PDFHypophosphatasia (HPP) is a rare inherited disorder characterized by the decreased activity of tissue-nonspecific alkaline phosphatase (TNSALP), caused by mutations in the gene. The aim of this study was to conduct differential diagnostics in HPP patients using whole-exome sequencing (WES). The medical records of HPP patients and the genetic testing of the gene were reviewed.
View Article and Find Full Text PDF