A cross-country comparison of temporal change in adolescent mental health problems in the UK and Brazil.

Aims: Epidemiological evidence shows a concerning rise in youth mental health difficulties over the past three decades. Most evidence, however, comes from countries in Europe or North America, with far less known about changes in other global regions. This study aimed to compare adolescent mental health across two population-based cohorts in the UK, and two population-based cohorts in Pelotas, Brazil.

Trypanosoma cruzi cell cycle progression exhibits minimal variation in histone PTMs with unique histone H4 acetylation pattern.

Histones are crucial proteins in eukaryotic cells that undergo extensive posttranslational modifications (PTMs) such as methylation, acetylation, and phosphorylation, which are associated to chromatin structure, gene expression, DNA damage/repair and cell cycle. In Trypanosoma cruzi, the primary sequence of histones differs from that of other eukaryotes. Despite this, they display a vast range of PTMs, though their modulation throughout the cell cycle remains largely unexplored.

Impact of manure and artificial fertilizer application on metal and metalloid distributions in agricultural soils and crops.

The application of animal manure to agricultural soil is a very common practice to improve soils fertility, providing a rich source of organic matter and nutrients. However, the presence of certain trace elements in the manure can result in a threat for food safety and the environment. In addition to their potential toxic effects on crops, animal and humans, certain metals such as cadmium, chromium, copper, nickel, mercury, cobalt, lead and zinc may play a role in the emergence and spread of antibiotic resistance, as they can increase the selective pressure on bacteria.

Does maternal anxiety predict child behavioral problems? An examination of internalizing and externalizing behaviors in children of participants in a Brazilian cohort study.

Maternal anxiety can have a significant impact on a child's behavior. This study aimed to investigate the association between maternal anxiety and externalizing and internalizing behavioral problems in their offspring. Data were utilized from 530 mothers and their 740 children participating in the 1993 Pelotas Birth Cohort and the 1993 Cohort-II study, respectively.

Profiling the Secretome of Glioblastoma Cells Under Histone Deacetylase Inhibition Using Mass Spectrometry.

Glioblastoma (GBM) is the most aggressive brain tumor, and different efforts have been employed in the search for new drugs and therapeutic protocols for GBM. A label-free, mass spectrometry-based quantitative proteomics has been developed to identify and characterize proteins that are differentially expressed in GBM to gain a better understanding of the interactions and functions that lead to the pathological state focusing on the extracellular matrix (ECM). The main challenge in GBM research has been to identify novel molecular therapeutic targets and accurate diagnostic/prognostic biomarkers.