Publications by authors named "A I Brombin"
Article Synopsis
- Melanocytes produce melanin, influencing the color of hair, eyes, and skin, and their lineage is linked to melanoma, a serious skin cancer.* -
- These cells develop from neural crest cells and are primarily found in the skin and hair, maintained by melanocyte stem cells.* -
- Understanding how melanocytes develop and function is crucial, as disruptions in these processes can lead to melanoma, and recent advances in cellular and genomic technologies provide new insights into this connection.*
Melanoma heterogeneity and plasticity underlie therapy resistance. Some tumour cells possess innate resistance, while others reprogramme during drug exposure and survive to form persister cells, a source of potential cancer cells for recurrent disease. Tracing individual melanoma cell populations through tumour regression and into recurrent disease remains largely unexplored, in part, because complex animal models are required for live imaging of cell populations over time.
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- McSCs in zebrafish are key for producing melanocytes during growth and repair, but their metabolic activation processes were unclear.
- The study found that dormant McSCs activate a neural crest program and switch to an Aldh2 metabolism to produce necessary components for cell growth and regeneration.
- Disruption of the one-carbon cycle impacted melanocyte regeneration, highlighting the importance of Aldh2 in providing metabolic support during this process.
A high incidence of foodborne diseases occurs in the home setting because consumers adopt inappropriate preparation, consumption, and storage procedures. The present study applies an ethnographic approach to identify inadequate practices that could increase the incidence of foodborne diseases. Techniques related to the ethnographic approach were used: participant observation, kitchens mapping, collection of photographic material, and informal interviews in natural settings.
View Article and Find Full Text PDFMelanocytes, the pigment-producing cells, are replenished from multiple stem cell niches in adult tissue. Although pigmentation traits are known risk factors for melanoma, we know little about melanocyte stem cell (McSC) populations other than hair follicle McSCs and lack key lineage markers with which to identify McSCs and study their function. Here we find that Tfap2b and a select set of target genes specify an McSC population at the dorsal root ganglia in zebrafish.
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