[Correction of the effect of vitamin K antagonists and antiplatelet agents in hemorrhagic stroke].

Background: Hemorrhagic stroke (HS) is associated with high risk of mortality or disability. To date, up to 25% of HSs are associated with anticoagulants and antiplatelet agents. Early hemostatic therapy and correction of effect of antithrombotic drugs in patients with HS significantly reduce the risk of adverse outcomes.

Thromboelastometry-Based Prophylaxis for Venous Thromboembolism in the Acute Period Following Isolated Severe Traumatic Brain Injury.

Objective: Traumatic brain injury (TBI) is an independent risk factor for venous thromboembolism (VTE). This study aimed to determine the optimal timing for initiating pharmacological thromboprophylaxis for VTE in patients with isolated severe TBI using rotational thromboelastometry (ROTEM).

Methods: This single-center observational study enrolled 115 patients aged 18-59 years with isolated severe TBI within the first 48 hours after injury.

Drug interactions in neurosurgical patients.

We analyzed literature data on the most common drug interactions in neurosurgical patients. Drug interactions are a potential cause of adverse and dangerous clinical events and outcomes. Awareness of nature of drug interactions is valuable to avoid negative consequences when using combination of several drugs.

Pulmonary embolism in neurosurgical patients.

Unlabelled: Pulmonary embolism (PE) is a serious problem for neurosurgical patients because of high risk of mortality and the need to choose effective and safe anticoagulation.

Objective: To analyze the patients with PE after neurosurgical interventions.

Material And Methods: A prospective study was performed at the Burdenko Neurosurgical Center between January 2021 and December 2022.

Infectious complications in acute period after traumatic brain injury.

Unlabelled: Patients with traumatic brain injury (TBI) are at high risk of infection.

Objective: To delineate infections in acute period of TBI, association between intracranial lesion type and risk of infection, as well as to estimate treatment outcomes in these patients depending on infection.

Material And Methods: This study included 104 patients with TBI (80 men and 24 women) aged 33.