[Functional activity of blood and liver cells under formaldehyde intoxication via inhalation].

The influence of formaldehyde (of 5 and 10 mg/m3) on the state of the antioxidant system the blood and liver of rats, the activity of pentose phosphate pathway enzymes, and weight of immune organs was investigated. Formaldehyde intoxication led to activation of lipid peroxidation processes in red blood cells and hepatocytes. In the liver cells these changes were accompanied by activation of the antioxidant and detoxification systems.

[The effect of phosphorylation on oxidative and CoA- and NAD+-independent turnover of pyruvate by pyruvate dehydrogenase complex in the brain].

It was shown that in the presence of ATP and Mg2+ the phosphorylation of the partially purified pyruvate dehydrogenase complex and the enzyme in isolated brain mitochondria inhibited the oxidative activity of the pyruvate dehydrogenase complex. The phosphorylation did no affect essentially the nonoxidative decarboxylation of pyruvate to form CO2 and acetaldehyde. In native mitochondria from the bovine brain the nonoxidative activity of the pyruvate dehydrogenase complex reached about 10% as compared to the oxidative activity of enzyme.

[Aldehyde dehydrogenase isoenzymes in the rat liver and their role in alcohol preference].

Isoenzymatic spectrum of aldehyde dehydrogenase (AIDH) has been studied in the liver of rats of both sexes. The absence or presence of the fourth isoenzyme of AIDH is apparently an indicator of predisposition of rats to ethanol consumption.