Publications by authors named "A I Balde"
Introduction: Human immunodeficiency virus (HIV) infection remains a major public health concern despite a significant decline in HIV-related mortality and morbidity. These significant advances are linked mostly to effective antiretroviral therapy (ART). However, these treatments are not without consequences on other microorganisms in our body, especially when they must be used for life.
View Article and Find Full Text PDFrVSVΔG-ZEBOV-GP and Ad26.ZEBOV, MVA-BN-Filo are WHO-prequalified vaccination regimens against Ebola virus disease (EVD). Challenges associated with measuring long-term clinical protection warrant the evaluation of immune response kinetics after vaccination.
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- This study investigates encapsulating the anti-inflammatory drug celecoxib (Cele) in microbeads made from carboxymethyl chitosan (CMCs) and sodium alginate (Alg) to enhance treatment for inflammatory bowel disease (IBD).
- The optimized microbeads show good mucoadhesivity (59.32%) and a sustained release of the drug over 24 hours, contrasting with the rapid release of the unencapsulated drug.
- Results indicate that Cele-loaded microbeads are non-toxic and effectively reduce nitric oxide generation and inflammation in cells, while also inhibiting the harmful COX-2 expression, showcasing their potential as a more effective treatment option.
Background: This study aimed to assess the seroprevalence of SARS-CoV-2 among children attending pediatric consultations in Bamako, Mali, using a rapid diagnostic test (RDT) on fingertip or venous blood samples.
Methods: A single-center, prospective cross-sectional study was conducted from May to September 2022 at the Pediatric Hospital in Bamako, Mali. Children aged 1 to 15 years underwent phlebotomy or fingertip blood sampling for SARS-CoV-2 antibody testing using the Abbott Panbio COVID-19 IgG/IgM Test.
Inflammation is an initial biological reaction that occurs in response to infection caused by foreign pathogens or injury. This process involves a tightly controlled series of signaling events at the molecular and cellular levels, with the ultimate goal of restoring tissue balance and protecting against invading pathogens. Malfunction in the process of inflammation can result in a diverse array of diseases, such as cardiovascular, neurological, and autoimmune disorders.
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