Publications by authors named "A I Arseniev"
Toll-like receptors (TLRs) are important players in the innate immune system. Binding of pathogen-related molecules to the extracellular domains of TLRs initiates signalosome assembly, a key event in signal transduction. Despite extensive research on individual receptor domains, the mechanism of signalosome assembly remains unclear.
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- Antibiotic streptolydigin (Stl) inhibits bacterial transcription by blocking RNA polymerase's active center, causing long pauses in transcription while not affecting average speed.
- Stl enhances brief pauses that lead to early stalled states in the transcription process, and surprisingly, factors GreA and GreB increase, rather than reduce, Stl's pausing effects.
- The study proposes a structural model of the transcription complex that provides insights into Stl's mechanism and suggests new ways to discover potential antibacterial agents.
The production of functionally active membrane proteins (MPs) in an adequate membrane environment is a key step in structural biology. Polymer-lipid particles based on styrene and maleic acid (SMA) represent a promising type of membrane mimic, as they can extract properly folded MPs directly from their native lipid environment. However, the original SMA polymer is sensitive to acidic pH levels, which has led to the development of several modifications: SMA-EA, SMA-QA, and others.
View Article and Find Full Text PDFNeurotrophin receptors of the Trk family are involved in the regulation of brain development and neuroplasticity, and therefore can serve as targets for anti-cancer and stroke-recovery drugs, antidepressants, and many others. The structures of Trk protein domains in various states upon activation need to be elucidated to allow rational drug design. However, little is known about the conformations of the transmembrane and juxtamembrane domains of Trk receptors.
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- - Lung cancer rates in Russia, particularly among men, have declined since the 1990s due to reduced smoking, but recent trends show rising incidence rates, especially in women since 2012, while mortality rates remain stable.
- - The study utilized national cancer reports and the Russian Fertility and Mortality Database from 1965-2021 to analyze changes in lung cancer incidence and mortality, revealing significant shifts starting around 2013 for men and 2012 for women.
- - An increase in the use of CT scans coincides with these trends, suggesting the need for ongoing monitoring to assess the impact of improved diagnostic methods on lung cancer outcomes in Russia.