Debate: differences and similarities between tension-type headache and migraine.

Tension-type headache (TTH) and migraine are two common primary headaches distinguished by clinical characteristics according to the 3 edition of the International Classification of Headache Disorders. Migraine is identified by specific features such as being more prevalent in females, being aggravated by physical activity, certain genetic factors, having photophobia, phonophobia, nausea, vomiting, or aura, and responding to specific drugs. Nonetheless, TTH and migraine share some common characteristics, such as onset occurring in the 20 s, and being triggered by psychological factors like stress, moderate pain severity, and mild nausea in chronic TTH.

Perturbed actin cap as a new personalized biomarker in primary fibroblasts of Huntington's disease patients.

Primary fibroblasts from patient's skin biopsies are directly isolated without any alteration in the genome, retaining in culture conditions their endogenous cellular characteristics and biochemical properties. The aim of this study was to identify a distinctive cell phenotype for potential drug evaluation in fibroblasts from Huntington's Disease (HD) patients, using image-based high content analysis. We show that HD fibroblasts have a distinctive nuclear morphology associated with a nuclear actin cap deficiency.

[The role of elderly people rights protection in effective NCDs control in current demographic situation].

The rapid aging of the population and the steady increase in life expectancy around the world is one of the greatest social, economic and political transformations of our time. The on-going demographic changes are accompanied by a significant increase in the prevalence of non-communicable diseases and disabled people. There is still no adequate medical care, as well as access to essential medicines and technologies for treatment and prevention of NCDs, what leads to disability, loss of productivity and reduction of national income in many regions of the world.

Involvement of IKAP in peripheral target innervation and in specific JNK and NGF signaling in developing PNS neurons.

A splicing mutation in the ikbkap gene causes Familial Dysautonomia (FD), affecting the IKAP protein expression levels and proper development and function of the peripheral nervous system (PNS). Here we attempted to elucidate the role of IKAP in PNS development in the chick embryo and found that IKAP is required for proper axonal outgrowth, branching, and peripheral target innervation. Moreover, we demonstrate that IKAP colocalizes with activated JNK (pJNK), dynein, and β-tubulin at the axon terminals of dorsal root ganglia (DRG) neurons, and may be involved in transport of specific target derived signals required for transcription of JNK and NGF responsive genes in the nucleus.

[International and national legal mechanisms of ensuring social justice for the elderly].

Increase in the proportion of older persons in the population of most countries entails a change in the scale and structure of morbidity, which requires higher expenditures on health care and social service. Maintaining health and activity of older people is an important indicator of the effectiveness of public policies in the field of health and social welfare. Under these conditions the development of effective measures to promote prosperous aging is required, which includes primarily legislative, administrative and other measures, as well as development of a strategy and action plan of socio-economic nature, taking into account the needs of older people.