Publications by authors named "A Huyghebaert"
About 70% of human cleavage stage embryos show chromosomal mosaicism, falling to 20% in blastocysts. Chromosomally mosaic human blastocysts can implant and lead to healthy new-borns with normal karyotypes. Studies in mouse embryos and human gastruloids showed that aneuploid cells are eliminated from the epiblast by p53-mediated apoptosis while being tolerated in the trophectoderm.
View Article and Find Full Text PDFHuman pluripotent stem cells (hPSCs) are pivotal in regenerative medicine, yet their in vitro expansion often leads to genetic abnormalities, raising concerns about their safety in clinical applications. This study analyzed ten human embryonic stem cell lines across multiple passages to elucidate the dynamics of chromosomal abnormalities and single-nucleotide variants (SNVs) in 380 cancer-related genes. Prolonged in vitro culture resulted in 80% of the lines acquiring gains of chromosome 20q or 1q, both known for conferring an in vitro growth advantage.
View Article and Find Full Text PDFArticle Synopsis
- - Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are linked neurodegenerative diseases, with the C9orf72 gene mutation being a common genetic cause due to the repeat of a hexanucleotide sequence (GGGGCC).
- - The research found that this GGGGCC sequence forms complex structures known as multimolecular G-quadruplexes (mG4s), which aggregate and contribute to the development of condensate formations associated with these diseases.
- - Increased levels of these G-quadruplex structures were detected in motor neurons from individuals with the C9orf72 mutation compared to healthy neurons, indicating that targeting these condensates could offer new therapeutic options for ALS/FTD.
Background & Aims: Sweetening agents are sugar substitutes with a low glycemic index, used to obtain a better glycemic control in diabetes patients. However, they also may have a role in other subjects, as a high glycemic index is thought to cause many pathological conditions. Unfortunately, not all artificial sweeteners are perceived as sweet as sugar by patients.
View Article and Find Full Text PDFRisk ranking priority of carcinogenic and/or genotoxic environmental contaminants in food in Belgium.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
January 2015
Article Synopsis
- * Contaminants are categorized into three priorities based on their risk levels and other potential harmful effects, with a focus on their carcinogenicity, genotoxicity, and exposure limits.
- * Arsenic and lead are identified as high-priority hazards that need immediate action due to their significant health risks, while other substances like cadmium and dioxins are classified as medium or low concern.