Publications by authors named "A Hutson"
Article Synopsis
- Immuno-oncology is revolutionizing cancer treatment, but most patients do not see long-lasting benefits, indicating a need for further advancements in the field.
- Computational immuno-oncology combines biomedical data science with oncology and immunology to enhance the development of effective immunotherapy treatments from research to clinical application.
- The review highlights 10 key challenges and opportunities in computational immuno-oncology, stressing the need for strong computational methods and teamwork to adapt to rapid changes in clinical demands and technology.
Circadian rhythms influence various physiological and behavioral processes such as sleep-wake cycles, hormone secretion, and metabolism. In , an important set of circadian output neurons are called pars intercerebralis (PI) neurons, which receive input from specific clock neurons called DN1. These DN1 neurons can further be subdivided into functionally and anatomically distinctive anterior (DN1a) and posterior (DN1p) clusters.
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- The study aimed to understand how inflammation within the perivascular tumor microenvironment (TME) influences the movement and effectiveness of T-cells in fighting ovarian tumors.
- Researchers found that moderate inflammation, triggered by a specialized oncolytic virus, led to better T-cell activity and less immune suppression compared to weak or strong inflammation.
- The results suggest that combining treatments could help T-cells better navigate the TME and improve their efficiency in combating cancer.
Article Synopsis
- The Letter reports the most accurate measurement so far of the matter-antimatter imbalance during Pb-Pb collisions at a high energy level of 5.02 TeV.
- It utilizes the Statistical Hadronization framework to determine precise values for the electric charge and baryon chemical potentials, μ_{Q} and μ_{B}.
- The analysis of antiparticle-to-particle yield ratios shows that the collisions create a system that is generally baryon-free and electrically neutral at midrapidity.
Background: Quantitating the contribution of phenotype-responsible elements in hypervirulent Klebsiella pneumoniae is needed.
Methods: Isogenic mutants of four hypervirulent clinical isolates that produced K1 (ST23), K2 (ST86), K20 (ST1544), or K54 (ST29) capsules (mean 2.2 log LD (range 1.