[Treatment of duodenal ulcer with pantoprazole. A multicenter study].

Background: The inhibition of H+/K(+)-ATPase (proton pump) of gastric parietal cells by substituted benzimidazoles represents a new therapeutic approach in conditions connected with hypersecretion of hydrochloric acid. Pantoprazol is the newest member of this group of drugs. Monotherapy of duodenal ulcer with pantoprazole or ranitidine was evaluated in terms of healing rate, tolerance and compliance.

[Campylobacter pylori--relation to gastric pathology and the effect of bismuth therapy].

Twenty-four patients with symptoms of gastric dyspepsia and active chronic gastritis in the antral mucosa were examined for the presence of Campylobacter pylori before and after treatment with bismuth salts (12 patients) and antacids (12 patients). Bismuth, contrary to the used antacid, significantly reduced the finding of C. pylori in the antral mucosa and had a favourable effect on the active form of chronic antral gastritis.