Single dose tinidazole prophylaxis in hysterectomy.

The results of this randomized double blind, placebo controlled trial of a single oral dose of 2 g tinidazole or placebo approximately 12 hours before hysterectomy showed the incidence of infective morbidity in patients who received placebo was 12.2% compared with 1.9% in patients who received tinidazole, (p = 0.

Methicillin-resistant Staphylococcus aureus bacteraemia.

Twenty-eight (53%) of 53 hospital-acquired staphylococcal bacteraemias which occurred at The Royal Melbourne Hospital over a two-year period were due to methicillin-resistant Staphylococcus aureus (MRSA). Every patient with MRSA bacteraemia had a significant underlying condition predisposing to nosocomial sepsis, and each had an intravascular foreign body in situ at the time. Most were being nursed in special care areas of the hospital and had been exposed to multiple or broad-spectrum antibiotics during the month before development of bacteraemia.

In-vitro activity of erythromycin against anaerobic microorganisms.

Minimum inhibitory concentrations of erythromycin were determined, in the absence of CO2, for 256 strains of anaerobic microorganisms recently isolated from clinical practice. Of 126 strains of Bacteroides fragilis, 93% were inhibited by 6 mg/L, or less, of erythromycin. Of the remaining 130 isolates, 92% were inhibited by 6 mg/L, or less, of erythromycin.

The emergence of gentamicin-resistant klebsiellae in a large general hospital.

Between March and December, 1975, an outbreak of infection with gentamicin-resistant Klebsiella pneumoniae (klebsiella (Gmr)) occurred at the Royal Melbourne Hospital. The klebsiellae were considered to be causing significant infection in 24 of 42 patients harbouring the microorganism. Commonest culture sources were urine and sputum, all but one of the significant urinary infections being associated with indwelling bladder catheters.