Publications by authors named "A Humm"
Article Synopsis
- The study examined acute ischemic stroke (AIS) in young adults aged 18 to 55 in Switzerland, focusing on risk factors, treatments, and outcomes between those with determined versus undetermined causes of stroke.
- Findings revealed that 22% of young AIS patients had undetermined pathogenesis, with higher rates of dyslipidemia and smoking in this group, as well as a tendency to receive intravenous thrombolysis.
- Despite a higher recurrence risk in the undetermined pathogenesis group, they experienced better functional outcomes at 3 months compared to those with a determined cause, particularly for those aged 46 to 55.
Article Synopsis
- The study investigates the relationship between infections or vaccinations and the onset of neuralgic amyotrophy (NA), a condition causing nerve pain and weakness.
- Conducted across multiple centers, the research involved matching NA patients with healthy controls while collecting clinical data and biological samples, focusing on prior infections and vaccinations.
- Results showed that 38.6% of NA cases had an identified immune trigger (either an infection or vaccination), with significant associations found between certain viral infections and the severity of the condition.
NADPH oxidases (NOX) are transmembrane proteins, widely spread in eukaryotes and prokaryotes, that produce reactive oxygen species (ROS). Eukaryotes use the ROS products for innate immune defense and signaling in critical (patho)physiological processes. Despite the recent structures of human NOX isoforms, the activation of electron transfer remains incompletely understood.
View Article and Find Full Text PDFBackground: Acute hepatitis E virus (HEV) infection has recently emerged as a potential trigger for acute dysimmune neuropathies, but prospective controlled studies are lacking.
Aims: To compare the frequency of concomitant acute HEV infection in patients with neuralgic amyotrophy (NA), Guillain-Barré syndrome (GBS), and Bell's palsy with a matched control population.
Methods: Swiss multicenter, prospective, observational, matched case-control study over 3 years (September 2019-October 2022).
Article Synopsis
- Proton-dependent oligopeptide transporters (POTs) play a key role in absorbing various dietary peptides and drugs, but understanding how they transport these different substrates has been a challenge.
- Researchers presented 14 X-ray structures of the bacterial POT DtpB with diverse di- and tripeptides, revealing important information about the transporter's flexible binding site.
- By studying binding affinities of over 80 peptides and using advanced techniques like molecular docking and machine learning, they found that peptides with compact hydrophobic residues are most effectively recognized by DtpB.