Does ruminating about the previous night's drinking during a hangover predict changes in heavy episodic drinking? A two-wave, 30-day prospective study.

Objective: We examined whether hangover-related rumination-repeatedly dwelling on negative aspects of yesterday's drinking while hungover the following morning-predicts changes in three dimensions of heavy episodic drinking (HED) over time.

Method: = 334 emerging adults (aged 19-29) from three Eastern Canadian universities who had recently experienced a hangover completed online self-report questionnaires at baseline (Wave 1) and 30 days later (Wave 2; 71.6% retention).

Cortex Suppress PD-L1 Expression in Cancer Cells and Potentiates Anti-Tumor Immunity in a Humanized PD-1/PD-L1 Knock-In MC-38 Colon Cancer Mouse Model.

Background/objectives: Immune checkpoints are essential for regulating excessive autoimmune responses and maintaining immune homeostasis. However, in the tumor microenvironment, these checkpoints can lead to cytotoxic T cell exhaustion, allowing cancer cells to evade immune surveillance and promote tumor progression. The expression of programmed death-ligand 1 (PD-L1) in cancer cells is associated with poor prognoses, reduced survival rates, and lower responses to therapies.

10(E)-Pentadecenoic Acid Inhibits Melanogenesis Partly Through Suppressing the Intracellular MITF/Tyrosinase Axis.

Melanogenesis, the biological process responsible for melanin synthesis, plays a crucial role in determining skin and hair color, photoprotection, and serving as a biomarker in various diseases. While various factors regulate melanogenesis, the role of fatty acids in this process remains underexplored. This study investigated the anti-melanogenic properties of 10(E)-pentadecenoic acid (10E-PDA) through both in silico and in vitro analyses.

First Investigation of the Spring Dietary Composition of Siberian Musk Deer () Using Next-Generation Sequencing.

Understanding the dietary composition of the Siberian musk deer () is critical for informing conservation efforts, particularly given the species' vulnerable status in the Republic of Korea and its limited ecological data. Previous dietary studies have relied on conventional methods with limitations in taxonomic precision, hindering comprehensive insights into their feeding ecology. To address this gap, we used Next-Generation Sequencing to analyze 16 fecal samples collected in April from Gangwon Province, the habitat of .