Publications by authors named "A Huggett"
Paws and Pathogens: A Multidisciplinary Approach Through Endocarditis and Hepatosplenic T-Cell Lymphoma.
J Investig Med High Impact Case Rep
July 2024
Article Synopsis
- Gram-negative coccobacilli are important pathogens that can lead to zoonotic infections in humans, especially causing infective endocarditis, which can be hard to diagnose.
- A 23-year-old male initially misdiagnosed with lymphoma was actually suffering from blood culture-negative endocarditis linked to these bacteria, showing symptoms like fevers, pancytopenia, and heart issues despite negative blood tests.
- The case emphasizes the need for careful consideration of these pathogens in patients with suspected endocarditis and highlights the importance of serological testing and a comprehensive treatment strategy for better patient outcomes.
A 39-year-old male with a history of intravenous drug use (IVDU) and no significant cardiovascular disease was admitted to the ICU for management of septic shock and acute hypoxic respiratory failure secondary to septic pulmonary emboli. Due to a high clinical suspicion for right-sided infective endocarditis (IE), he received a transthoracic echocardiogram (TTE), which did not reveal any vegetations. However, a transesophageal echocardiogram (TEE) was subsequently performed; this showed a large 2.
View Article and Find Full Text PDFBackground: Short courses of antibiotics (7-10 days) are effective for uncomplicated gram-negative bloodstream infections (GN-BSI). However, prior studies have been limited to small cohorts of critically ill patients.
Objective: The objective of this study was to evaluate the safety and efficacy of short courses of therapy compared with longer courses in patients admitted to the intensive care unit (ICU) with GN-BSI.
We sought to determine if opioid exposure may have a detrimental effect on the course of infection (CDI). We compared opioid exposure in patients with well-defined severe CDI and non-severe CDI. Following exclusions, 403 records were reviewed.
View Article and Find Full Text PDFWe report the hydrothermally enhanced hydrolysis of polyacrylonitrile (PAN) in neutral water, which generates photoluminescent polymers with low unsaturation degrees. Despite the hydrophobic nature of PAN, the product can be dissolved in water at a high concentration (≥100 g/L). The product exhibits complete absence of alkenes or aromatic structures, and photoluminescence originates from newly formed N- and O-containing groups.
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