Cellular and microenvironmental cues that promote macrophage fusion and foreign body response.

During the foreign body response (FBR), macrophages fuse to form foreign body giant cells (FBGCs). Modulation of FBGC formation can prevent biomaterial degradation and loss of therapeutic efficacy. However, the microenvironmental cues that dictate FBGC formation are poorly understood with conflicting reports.

Targeting Macrophage Polarization for Reinstating Homeostasis following Tissue Damage.

Tissue regeneration and remodeling involve many complex stages. Macrophages are critical in maintaining micro-environmental homeostasis by regulating inflammation and orchestrating wound healing. They display high plasticity in response to various stimuli, showing a spectrum of functional phenotypes that vary from M1 (pro-inflammatory) to M2 (anti-inflammatory) macrophages.

Dynamical Explanation of the Dark Matter and Baryon Energy Density Coincidence.

The near equality of the dark matter and baryon energy densities is a remarkable coincidence, especially when one realizes that the baryon mass is exponentially sensitive to UV parameters in the form of dimensional transmutation. We explore a new dynamical mechanism, where in the presence of an arbitrary number density of baryons and dark matter, a scalar adjusts the masses of dark matter and baryons until the two energy densities are comparable. In this manner, the coincidence is explained regardless of the microscopic identity of dark matter and how it was produced.