Plasticity of Human Microglia and Brain Perivascular Macrophages in Aging and Alzheimer's Disease.

The complex roles of myeloid cells, including microglia and perivascular macrophages, are central to the neurobiology of Alzheimer's disease (AD), yet they remain incompletely understood. Here, we profiled 832,505 human myeloid cells from the prefrontal cortex of 1,607 unique donors covering the human lifespan and varying degrees of AD neuropathology. We delineated 13 transcriptionally distinct myeloid subtypes organized into 6 subclasses and identified AD-associated adaptive changes in myeloid cells over aging and disease progression.

A Pilot Study of a Novel Dietary Intervention Targeting Ultra-Processed Food Intake.

Background: Ultra-processed foods (UPFs) are harmful to health but ubiquitous in the modern food environment, comprising almost 60% of the average American diet. This study assessed the feasibility, acceptability, and preliminary efficacy of a novel behavioral intervention designed to reduce UPF intake.

Methods: Fourteen adults participated in an 8-week pilot intervention, which consisted of weekly group sessions, individual meal planning sessions, and financial support.

Physician Reasons for or Against Treatment Intensification in Patients With Metastatic Prostate Cancer.

Importance: Clarifying the underutilization of treatment intensification (TI) for metastatic castration-sensitive prostate cancer (mCSPC) may improve implementation of evidence-based medicine and survival outcomes.

Objective: To investigate physicians' beliefs about TI in mCSPC to understand the gap between evidence-based guidelines and clinical practice.

Design, Setting, And Participants: This survey study analyzed data from the Adelphi Real World retrospective survey, which comprised physician surveys that were linked to medical record reviews of US adult patients treated for mCSPC between July 2018 and January 2022.

Biological hazards of micro- and nanoplastic with adsorbents and additives.

With the increased worldwide production of plastics, interest in the biological hazards of microplastics (MP) and nanoplastics (NP), which are widely distributed as environmental pollutants, has also increased. This review aims to provide a comprehensive overview of the toxicological effects of MP and NP on and systems based on studies conducted over the past decade. We summarize key findings on how the type, size, and adsorbed substances of plastics, including chemical additives, impact organisms.

Application of machine learning for delirium prediction and analysis of associated factors in hospitalized COVID-19 patients: A comparative study using the Korean Multidisciplinary cohort for delirium prevention (KoMCoDe).

Background: The incidence of delirium in hospitalized coronavirus disease 2019 (COVID-19) patients is linked to adverse health outcomes. Predicting the occurrence and risk factors of delirium is key to preventing its sudden onset.

Aims: To explore the factors associated with delirium in hospitalized COVID-19 patients and to compare the performance of various machine learning (ML) techniques for future use in predicting delirium.