Residual β-cell function and the insulin-like growth factor system in Danish children and adolescents with type 1 diabetes.

Context: C-peptide-positive adults with type 1 diabetes (T1D) have higher circulating total and free IGF-1 and lower IGF binding protein 1 (IGFBP-1) than C-peptide-negative patients. Whether this is also the case in children remains unknown.

Objective: The objective of the study was to examine the IGF system in children/adolescents with and without residual β-cell function (RBF).

Pegvisomant therapy in pituitary gigantism: successful treatment in a 12-year-old girl.

Objective: The use of a growth hormone (GH) receptor antagonist, pegvisomant has shown great promise in adults with acromegaly, but experience in paediatric patients is lacking. We aimed to describe the results of pegvisomant therapy in a 12-year-old girl with an aggressive GH-secreting pituitary tumour.

Design: To evaluate the ability of pegvisomant therapy to control the effects of peripheral GH excess in a case of pituitary gigantism.

Cushing's disease in childhood as the first manifestation of multiple endocrine neoplasia syndrome type 1.

Objective: To describe three cases of Cushing's disease in children with multiple endocrine neoplasia type 1 (MEN1), as clinical manifestations of MEN1 are very rare in childhood.

Design And Methods: A retrospective review of three cases of Cushing's disease diagnosed between 1997 and 1999. Genetic screening for MEN1 gene mutation was performed in each patient.