Publications by authors named "A Hock"
Article Synopsis
- Androgen receptor (AR) signaling is crucial in the development of prostate cancer, prompting research into effective treatments.
- The study focused on creating and refining AR PROTAC degraders, which work by recruiting the Cereblon (CRBN) E3 ligase to induce AR degradation.
- The lead compound, AZ'3137, exhibited strong degradation of AR and its L702H mutant, good oral bioavailability, and effectively inhibited AR signaling and tumor growth in mouse models.
Unlocking novel E3 ligases for use in heterobifunctional PROTAC degraders is of high importance to the pharmaceutical industry. Over-reliance on the current suite of ligands used to recruit E3 ligases could limit the potential of their application. To address this, potent ligands for DCAF15 were optimized using cryo-EM supported, structure-based design to improve on micromolar starting points.
View Article and Find Full Text PDFTobacco smoking is one of the main causes of premature death worldwide and quitting success remains low, highlighting the need to understand the neurobiological mechanisms underlying relapse. Preclinical models have shown that the amygdala and glutamate play an important role in nicotine addiction. The aims of this study were to compare glutamate and other metabolites in the amygdala between smokers and controls, and between different smoking states.
View Article and Find Full Text PDFThe photoantimicrobial potential of four mushroom species (i.e., , , , and ) was explored by studying the minimal inhibitory concentrations (MIC) via a light-modified broth microdilution assay based on the recommended protocols of the European Committee on Antimicrobial Susceptibility Testing (EUCAST).
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