Publications by authors named "A Hiraki"
Necrotizing sialometaplasia (NSM) is a non-neoplastic lesion listed in the WHO classification of Head and Neck Tumours. In early NSM lesion, there is infarction and necrosis of the acinar cells and squamous metaplasia of the salivary ducts occurs as the lesion matures. Differentiation from squamous cell carcinoma and other malignancies is sometimes required clinically and histopathologically.
View Article and Find Full Text PDFBackgrounds: To the best of our knowledge, there are no reports of proteomic analysis for the identification of unknown proteins involved in resistance to anaplastic lymphoma kinase (ALK) inhibitors. In this study, we investigated the proteins involved in resistance to alectinib, a representative ALK inhibitor, through proteomic analysis and the possibility of overcoming resistance.
Methods: An ALK-positive lung adenocarcinoma cell line (ABC-11) and the corresponding alectinib-resistant cell line (ABC-11/CHR2) were used.
The combined inhibition of SLC1A3 and glutaminase in osimertinib-resistant EGFR mutant cells.
Biochim Biophys Acta Gen Subj
October 2024
Article Synopsis
- Researchers studied osimertinib-resistant EGFR-mutant lung cancer to uncover the resistance mechanisms using specialized cell lines developed through exposure to the drug.
- They found that SLC1A3, a transporter for glutamic acid, was significantly more active in resistant cells, and targeting it with specific inhibitors increased drug sensitivity.
- The results suggest that combining osimertinib with a glutaminase inhibitor could effectively counteract resistance and improve treatment outcomes for patients with this type of lung cancer.
Article Synopsis
- - Necrotising sialometaplasia (NSM) is a non-cancerous growth mostly found in the minor salivary glands, presenting as swelling and potentially ulceration, often mimicking cancer like squamous cell carcinoma.
- - Histopathologically, NSM is characterized by lobular structures, acinar infarction, and changes in the salivary ducts, with an unknown cause that requires careful distinction from malignant conditions.
- - The study investigates the role of the TGF-β3 gene, finding that it is upregulated in NSM and may contribute to the condition by inhibiting cell growth and causing cell type changes during healing and tissue regeneration.
Ameloblastoma (AB) is the most common benign, epithelial odontogenic tumor that occurs in the jawbone. AB is a slow-growing, benign epithelial tumor but shows locally invasive growth, with bone resorption or recurrence if not adequately resected. From these points of view, understanding the mechanism of AB-induced bone resorption is necessary for better clinical therapy and improving patients' quality of life.
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