Publications by authors named "A Hilgendorff"
Lung fibrosis development utilizes alveolar macrophages, with mechanisms that are incompletely understood. Here, we fate map connective tissue during mouse lung fibrosis and observe disassembly and transfer of connective tissue macromolecules from pleuro-alveolar junctions (PAJs) into deep lung tissue, to activate fibroblasts and fibrosis. Disassembly and transfer of PAJ macromolecules into deep lung tissue occurs by alveolar macrophages, activating cysteine-type proteolysis on pleural mesothelium.
View Article and Find Full Text PDFIdiopathic pulmonary fibrosis (IPF) is a lethal chronic lung disease characterized by aberrant intercellular communication, extracellular matrix deposition, and destruction of functional lung tissue. While extracellular vesicles (EVs) accumulate in the IPF lung, their cargo and biological effects remain unclear. We interrogated the proteome of EV and non-EV fractions during pulmonary fibrosis and characterized their contribution to fibrosis.
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- The text discusses the introduction of "ehrapy," an open-source Python framework designed for comprehensive analysis of electronic health records (EHRs) and epidemiology data, addressing the lack of tools for heterogeneous data exploration.
- ehrapy streamlines various analytical processes including data extraction, quality control, and statistical analysis, allowing researchers to explore patient-disease associations, compare patient groups, and analyze treatment impacts, among other features.
- The framework is exemplified through six case studies, showcasing its application in patient stratification for pneumonia, survival analysis, cardiovascular risk evaluation, and bias detection in EHRs, with the goal of standardizing analysis pipelines in biomedical research.
Article Synopsis
- Researchers studied how mild SARS-CoV-2 infections during pregnancy affect fetal lung growth, especially during the omicron phase of the pandemic.
- They used MRI to check the lung volumes of 24 pregnancies and found no significant differences compared to normal values.
- This study shows that mild SARS-CoV-2 infections don't harm fetal lung development like earlier variants did, possibly due to the benefits of vaccination or prior infections.
Oxygen toxicity constitutes a key contributor to bronchopulmonary dysplasia (BPD). Critical step in the pathogenesis of BPD is the inflammatory response in the immature lung with the release of pro-inflammatory cytokines and the influx of innate immune cells. Identification of efficient therapies to alleviate the inflammatory response remains an unmet research priority.
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