Antimanic-like effect of dipyridamole in the methylphenidate-induced hyperlocomotion.

Background: Adenosinergic system has been implicated in the pathophysiology of bipolar disorder and drugs that affect adenosine neurotransmission have shown some efficacy as add-on therapy in manic patients.

Objective: Thus, the aim of the present study was to screen adenosinergic drugs for antimanic-like effect in methylphenidate (MPH)-induced hyperlocomotion in mice.

Methods: Male and female Swiss mice received a single allopurinol (50 and 200 mg/kg, ip), dipyridamole (20 mg/kg, ip), or inosine (50 mg/kg, ip) administration before an acute MPH challenge (5 mg/kg, sc).

Predictive maintenance and safety operation by device integration on the QUEST large experimental device.

As technology has improved in recent years, it has become possible to create new valuable functions by combining various devices and sensors in a network. This concept is referred to as the Internet of Things (IoT), and predictive maintenance is a new valuable function associated with the IoT. In large-scale experimental facilities with many researchers, it is not desirable that experiments cannot be performed due to sudden failure of equipment.

Impaired early-phase suppression of glucagon secretion after glucose load is associated with insulin requirement during pregnancy in gestational diabetes.

Aims/introduction: The role of glucagon abnormality has recently been reported in type 2 diabetes; however, its role in gestational diabetes mellitus (GDM) is still unknown. The glucose intolerance in GDM is heterogeneous, and not all patients require insulin treatment during pregnancy. Here, we investigated whether glucagon abnormality is associated with the requirement for insulin treatment during pregnancy.