Publications by authors named "A Heyraud"

Inorganic/organic hybrid biomaterials have been developed to obtain synergy of the inorganic and organic co-networks for implant and 3D printed scaffold applications, providing combinations of bioactivity, toughness and controlled biodegradation. SiO-CaO/PTHF/PCL-diCOOH sol-gel hybrids previously showed potential for osteogenesis due to the addition of calcium to the silicate network of the hybrid, using calcium methoxyethoxide (CME) as the calcium source. Here, we investigate other calcium sources to improve mechanical properties and printability of the hybrid inks.

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Article Synopsis
  • Anatomical 3D-printed nasal casts are important for studying how drugs are delivered inside the nose and provide unique preclinical data not available from animal studies.
  • The study analyzed CT scans from 98 patients, revealing anatomical differences in the nasal cavity and identifying three distinct nasal geometry groups, leading to the creation of representative 3D models.
  • The research demonstrated that these anatomical variations significantly impact how well different medical devices deliver drugs, especially with nasal sprays and nebulizers, highlighting the need for diverse models to assess drug effectiveness in different populations.
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This study demonstrates that dissolution products of inorganic/organic SiO-CaO/PTHF/PCL-diCOOH hybrid (70S30C-CL) drive human bone marrow stromal cells (h-BMSCs) down an osteogenic pathway with the production of mineralised matrix. We investigated osteogenesis through combined analyses of mRNA dynamics for key markers and targeted staining of mineralised matrix. We demonstrate that h-BMSCs undergo accelerated differentiation in vitro in response to the 70S30C-CL ionic milieu, as compared to incubation with osteogenic media.

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This study evaluated the use of silica/poly(tetrahydrofuran)/poly(ε-caprolactone) (SiO/PTHF/PCL-diCOOH) 3D-printed scaffolds, with channel sizes of either 200 (SC-200) or 500 (SC-500) µm, as biomaterials to support the chondrogenesis of sheep bone marrow stem cells (oBMSC), under in vitro conditions. The objective was to validate the potential use of SiO/PTHF/PCL-diCOOH for prospective in vivo ovine studies. The behaviour of oBMSC, with and without the use of exogenous growth factors, on SiO/PTHF/PCL-diCOOH scaffolds was investigated by analysing cell attachment, viability, proliferation, morphology, expression of chondrogenic genes (RT-qPCR), deposition of aggrecan, collagen II, and collagen I (immunohistochemistry), and quantification of sulphated glycosaminoglycans (GAGs).

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Biomaterials that can improve the healing of articular cartilage lesions are needed. To address this unmet need, we developed novel 3D printed silica/poly(tetrahydrofuran)/poly(ε-caprolactone) (SiO/PTHF/PCL-diCOOH) hybrid scaffolds. Our aim was to carry out essential studies to advance this medical device towards functional validation in pre-clinical trials.

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