Structural connectivity of low-frequency subthalamic stimulation for improving stride length in Parkinson's disease.

Background: A reduction in stride length is considered a key characteristic of gait kinematics in Parkinson's disease (PD) and has been identified as a predictor of falls. Although low-frequency stimulation (LFS) has been suggested as a method to improve gait characteristics, the underlying structural network is not well understood.

Objective: This study aims to investigate the structural correlates of changes in stride length during LFS (85 Hz).

Subthalamic 85 Hz deep brain stimulation improves walking pace and stride length in Parkinson's disease patients.

Background: Mobile gait sensors represent a compelling tool to objectify the severity of symptoms in patients with idiopathic Parkinson's disease (iPD), but also to determine the therapeutic benefit of interventions. In particular, parameters of Deep Brain stimulation (DBS) with its short latency could be accurately assessed using sensor data. This study aimed at gaining insight into gait changes due to different DBS parameters in patients with subthalamic nucleus (STN) DBS.

Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells.

Xanthones from the tropical fruit mangosteen (Garcinia mangostana) display anti-inflammatory and anti-oxidative activities. Here, we isolate and identify potential inducers of the aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways from mangosteen using a bioassay-guided strategy. Mangosteen fruit pericarp extracts were subjected to sequential solvent extractions, followed by chromatography coupled with NMR spectroscopy and mass spectrometric analyses for identification and isolation of pure compounds.

Long-term follow-up of cystic fibrosis newborn screening: psychosocial functioning of adolescents and young adults.

Background: Long-term psychosocial outcomes of cystic fibrosis (CF) patients diagnosed through newborn screening remain unknown.

Methods: This cross-sectional study compared three groups of youths (16 to 22 years): CF patients diagnosed through NBS (CF-NBS, n = 13), CF patients diagnosed through standard practice (CF-SP, n = 26) and healthy peers (H, n = 42), plus 72 of their parents. We hypothesized that adolescent psychological functioning would be mediated by parent depression and quality of parent-child communication and cohesiveness.

Changes of water-relation characteristics and levels of organic cytoplasmic solutes during salinity induced transition of Mesembryanthemum crystallinum from C-photosynthesis to crassulacean acid metabolism.

NaCl was added to the nutrient solution of 4-6-week old Mesembryanthemum crystallinum plants so that the concentration rose by 50 mM per day. Ten to fifteen days after a concentration of 400 mM was reached, pronounced diurnal oscillations of malate levels indicated that plants had changed from C-photosynthesis to crassulacean acid metabolism (CAM). Due to the NaCl-treatment the solute potential (Ψ) decreased from about -6 bar to -25 bar, and the water potential (Ψ) changed from about -5 bar to -23 bar on average.