Publications by authors named "A Hershko"

Article Synopsis
  • Health care disparities are differences in health and access to health care influenced by various governmental, social, economic, and environmental policies.
  • The American Academy of Allergy, Asthma & Immunology (AAAAI) initiated a forum to explore these disparities globally, starting with the Middle East, where representatives from Egypt, Israel, Lebanon, and Iran discussed their diverse health care systems.
  • Despite the region's conflicts and unique challenges, the forum highlighted the need for international collaboration to address these disparities in allergy and immunology, focusing on patient education and improving access to specialized care.
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The ubiquitin ligase Anaphase-Promoting Complex/Cyclosome (APC/C) and its regulatory protein Cdc20 play important roles in the control of different stages of mitosis. APC/C associated with Cdc20 is active and promotes metaphase-anaphase transition by targeting for degradation inhibitors of anaphase initiation. Earlier in mitosis, premature action of APC/C is prevented by the mitotic checkpoint (or spindle assembly checkpoint) system, which ensures that anaphase is not initiated until all chromosomes are properly attached to the mitotic spindle.

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Background: The mRNA-based COVID-19 vaccine was introduced to the general public in December 2020. Shortly thereafter, safety concerns were raised due to the reporting of allergic reactions. Allergy-related disorders were suspected to be significant risk factors and the excipient polyethylene glycol was suggested to be a robust allergen.

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