Ask, do not tell: consulting a patient advisory board to understand unmet needs of patients with GVHD in Europe.

Graft-versus-host disease (GVHD) is a complication of hematopoietic cell transplantation (HCT) that has a low chance of complete remission and a substantial effect on morbidity and mortality. To better understand how to improve the field of GVHD research, management, and care, the cGVHD Eurograft Initiative organised a European community advisory board of patient advocates, with the assistance of the Lymphoma Coalition, to identify unmet needs. We present the results of this project in this Viewpoint, which identify unmet GVHD needs from the patient advocates' perspectives and provide five key actionable themes to improve GVHD management and care.

Modification of the course of disease progression in idiopathic pulmonary fibrosis by pirfenidone: evidence of the potential for disease reversal.

Idiopathic pulmonary fibrosis (IPF) is a fibrosing pneumonia of unknown causation with a chronic, progressive course that may be modified by treatment with the antifibrotic agents, pirfenidone and nintedanib. Both drugs have been shown to slow disease progression, but, in rare cases, pirfenidone has been shown to stabilise and even improve lung function. We present a case of a patient whose lung function and pathognomonic features on CT imaging improved significantly on commencement of treatment with pirfenidone.

Soil and vegetation property data from the Ultuna R3-RAM56 long-term soil amendment experiment, 1956-2023.

The R3-RAM56 long-term experiment in Ultuna, Sweden has tracked the effect of organic and inorganic amendments on agricultural crop and soil properties for the past almost 70 years. Aboveground crop biomass has been collected annually since the beginning of the experiment, while topsoil samples were collected three times in the first twenty years and every other year since 1963. We report crop yields and nutrient content, as well as carbon, nitrogen, and micronutrient content for soils and amendments.

Pepticombisomes: Biomimetic Vesicles Crafted From Recombinant Supercharged Polypeptides with Uniformly Distributed Side-Chains.

Cell membranes play a key role in bottom-up synthetic biology, as they enable interaction control, transport, and other essential functions. These ultra-thin, flexible, yet stable structures form through the self-assembly of lipids and proteins. While liposomes are common mimics, their synthetic membranes often fail to replicate natural properties due to poor structural control.

Concepts of healthy and environmentally sustainable diets clash with a life in transition - Findings from a qualitative study in urban Burkina Faso.

Background: Sub-Saharan African countries like Burkina Faso face a dietary transition and are experiencing a shift in disease burden.

Objective: We explored perceptions of healthy and environmentally sustainable dietary habits in urban Burkina Faso in order to tailor nutritional interventions to the local population and ultimately improve public and planetary health.

Methods: We conducted an exploratory qualitative study with semi-structured face-to-face interviews in three informal and two formal neighborhoods of Ouagadougou.