Publications by authors named "A Herrig"

Participatory workplace interventions to improve workforce musculoskeletal health are infrequently analysed regarding why they work, for whom or under what circumstances. This review sought to identify intervention strategies which achieved genuine worker participation. In total, 3388 articles on participatory ergonomic (PE) interventions were screened; 23 were suitable to analyse within a realist framework identifying contexts, mechanisms of change, and outcomes.

View Article and Find Full Text PDF

Daily rhythms occur in numerous physiological and behavioral processes across an immense diversity of taxa, but there remain few cases in which mechanistic links between rhythms of trait expression and organismal fitness have been established. We construct a dynamic optimization model to determine whether risk allocation provides an adaptive explanation for the daily foraging rhythm observed in many species using the orb-weaving spider Cyclosa turbinata as a case study. Our model predicts that female C.

View Article and Find Full Text PDF

Relevant to drivetrain bearing fatigue failures, we analyse non-steady wind turbine responses from interactions between energy-dominant daytime atmospheric turbulence eddies and the rotating blades of a GE 1.5 MW wind turbine using a unique dataset from a GE field experiment and computer simulation. Time-resolved local velocity data were collected at the leading and trailing edges of an instrumented blade together with generator power, revolutions per minute, pitch and yaw.

View Article and Find Full Text PDF

Rad23 is an adaptor protein that binds to both ubiquitinated substrates and to the proteasome. Despite its association with the proteasome, Rad23 escapes degradation. Here we show that Rad23 remains stable because it lacks an effective initiation region at which the proteasome can engage the protein and unfold it.

View Article and Find Full Text PDF
Article Synopsis
  • Dyskeratosis congenita (DC) is a genetic disorder marked by skin pigmentation issues, nail problems, and an increased cancer risk, predominantly caused by mutations related to telomerase.
  • Keratinocytes from patients with an autosomal dominant form of DC display shortened telomeres and reduced lifespan, alongside impaired cell functions like colony formation and migration.
  • Introducing components of the telomerase complex, specifically TERT and TERC, can partially restore telomerase activity and improve the lifespan of skin cells, highlighting significant differences between DC keratinocytes and fibroblasts in terms of cellular behavior and response to genetic manipulation.
View Article and Find Full Text PDF