Publications by authors named "A Hernanz-Lobo"
Article Synopsis
- Immune-based TB diagnostic tests currently have low sensitivity in children and struggle to differentiate between latent TB infection (LTBI) and active TB disease.
- The study analyzed 17 biomarkers in plasma from children with confirmed TB, LTBI, and non-TB infections, finding significant biomarkers like IFN-γ and IL-2 that effectively predicted TB status.
- The IFN-γ/MCP-1 ratio emerged as the most promising combination for distinguishing between MTB-infected and non-infected children, suggesting a need for further research to improve pediatric TB diagnosis.
A Local Experience of Antibiotic Lock Therapy as an Adjunctive Treatment for Central Venous Catheter-Related Bloodstream Infections in Pediatric Oncology and Hematology Patients.
Children (Basel)
August 2024
Background: One of the main drawbacks of tunneled central venous catheters (CVCs) is catheter-related bloodstream infections (CRBSIs). Antibiotic lock therapy (ALT) can be combined with systemic antibiotics to achieve catheter salvage. Our objectives are to describe cases of CRBSI and our experience with ALT in a pediatric oncology-hematology ward.
View Article and Find Full Text PDFBackground: Tuberculosis (TB) remains a major cause of morbidity and death worldwide, with a significant impact on children, especially those under the age of 5 years. The complex diagnosis of pediatric TB, compounded by limited access to more accurate diagnostic tests, underscores the need for improved tools to enhance diagnosis and care in resource-limited settings.
Objective: This study aims to present a telemedicine web platform, BITScreen PTB (Biomedical Image Technologies Screen for Pediatric Tuberculosis), aimed at improving the evaluation of pulmonary TB in children based on digital chest x-ray (CXR) imaging and clinical information in resource-limited settings.
Article Synopsis
- Tuberculosis is a major global health issue, with children representing a significant proportion of cases and deaths, making early diagnosis challenging, especially in resource-limited settings.
- A multicenter study across Mozambique, South Africa, and Spain will assess the availability of imaging resources and radiation exposure for pediatric TB diagnosis, utilizing retrospective data and standardized surveys among clinicians and radiology staff.
- Data collected will include national inventories of imaging units, survey results on diagnostic practices, and analyses of radiation doses for children under 16, aiming to improve diagnosis and safety in pediatric TB management.
Background: It is known that SARS-CoV-2 antibodies from pregnant women with SARS-CoV-2 infection during pregnancy cross the placenta but the duration and the protective effect of these antibodies in infants is scarce.
Methods: This prospective study included mothers with SARS-COV-2 infection during pregnancy and their infants from April 2020 to March 2021. IgG antibodies to SARS-CoV-2 spike protein were performed on women and infants at birth and at two and six months during follow-up.