Publications by authors named "A Hernandez-Hernandez"
Acute myeloid leukaemia (AML) is a highly heterogeneous malignancy, with a poor 5-year overall survival rate of approximately 30%. Consequently, the search for novel therapeutic strategies is ongoing, and the identification of new vulnerabilities could accelerate progress. Oxidative stress and metabolic rewiring are established hallmarks of cancer, and recent evidence suggests that NADPH oxidases may regulate metabolism, potentially linking these two processes.
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- Self-care and empowerment in heart failure (HF) patients are crucial for better health outcomes, but there is limited information on their understanding of the condition and satisfaction with care.
- A study involving 281 patients from 14 heart failure units revealed that patients had a good grasp of their condition, with an average knowledge score of 80.7%, although some gaps remain.
- Despite these knowledge gaps, the majority of participants expressed high satisfaction with their care, with 98.2% likely to recommend the heart failure units to others.
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- The study evaluated the Single-Step Pedicle Screw System (SSPSS), a method for placing screws in minimally invasive spine surgery, that does not use traditional tools like K-wires.
- Researchers compared the planned screw paths with actual positions using CT scans after surgeries on patients who received lumbar interbody fusion.
- Results showed 95% accuracy in screw placements with no complications, suggesting SSPSS is a reliable alternative for pedicle screw placement.
T-cell activation is central for the initiation of T cell mediated adaptive immune response and is the result of the close communication between the Antigen Presenting Cell (APC) and the T lymphocyte. Although T-cell activation is currently well understood, and many intracellular pathways are well characterized, nevertheless new players are constantly identified, and this complements the known protein interactome. In this work we aimed to identify new proteins involved in T cell activation.
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