Publications by authors named "A Hernandez-Gallego"
Non-small cell lung cancers (NSCLC) are the most common type of lung cancer and can be classified according to the presence of mutually exclusive oncogenic drivers. The majority of NSCLC patients present a non-actionable oncogenic driver, and treatment resistance through the amplification of the () or the expression of programmed cell death protein 1 ligand (PD-L1) is common. Herein, we investigated the relation between gene amplification and PD-L1 expression in patients with advanced NSCLC and no other actionable oncogenic driver (i.
View Article and Find Full Text PDFAntigen presenting cells from the cervical mucosa are thought to amplify incoming HIV-1 and spread infection systemically without being productively infected. Yet, the molecular mechanism at the cervical mucosa underlying this viral transmission pathway remains unknown. Here we identified a subset of HLA-DR CD14 CD11c cervical DCs at the lamina propria of the ectocervix and the endocervix that expressed the type-I interferon inducible lectin Siglec-1 (CD169), which promoted viral uptake.
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- A study investigated the significance of acute histological activity (AHA) in predicting clinical relapse (CR) among ulcerative colitis (UC) patients who were in remission.
- The research included 113 patients who had left-sided or extensive UC and were undergoing colonoscopies from 2005 to 2015, assessing their biopsy samples for inflammatory activity.
- Findings indicated that the presence of AHA, especially when combined with a flare in the past year, was a significant risk factor for relapse, highlighting the importance of histological evaluation in managing UC.