Publications by authors named "A Hensel"
Article Synopsis
- - The study focuses on finding inhibitors that prevent the fusion of the herpes simplex virus type 1 (HSV-1) with host cell membranes, utilizing a virus-free cell culture system to model the fusion process.
- - Researchers identified aescin, a saponin mixture, as a specific inhibitor of HSV-1 membrane fusion, achieving significant reductions in viral entry and spread in cell assays.
- - Analytical methods revealed the main compounds present in aescin and their varying functionalities, with aescin IA showing promising inhibitory properties against HSV-1.
Parasitic infections with gastrointestinal nematodes are a serious problem for the health and welfare of domestic animals and negatively affect the economics of animal production. Haemonchus contortus is a haematophagous nematode of small ruminants responsible for significant mortality and morbidity. In addition, the widespread resistance to synthetic anthelmintic drugs emphasizes the urgent need of alternative treatment options against haemonchosis.
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- Tannin-rich plants in Africa are explored for their potential as natural treatments against parasitic nematodes in humans and livestock.
- Recent research highlights that while compounds like procyanidin C1 and geraniin show effectiveness against hookworm and whipworm larvae in their unprocessed forms, their efficacy significantly diminishes after being metabolized by gut microbiota.
- The study utilized human fecal suspensions to simulate metabolism and found that both the tannin extracts and their active compounds lost their anthelmintic effects after fermentation, indicating the need for further research on the metabolites' roles.
Limonium brasiliense rhizomes extract against virulence factors of Porphyromonas gingivalis: Inhibition of gingipains, bacterial adhesion, and biofilm formation.
Fitoterapia
September 2024
Periodontitis is clinically characterized by destruction of the tooth support system and tooth loss. Porphyromonas gingivalis (Pg) plays a dominant role in periodontitis. Fractions and isolated compounds from an acetone-water extract of the roots of Limonium brasiliense (Lb) were tested in vitro for their anti-adhesive capacity against Pg on human KB buccal cells, influence on gingipains, the main virulence factors of Pg, and biofilm formation.
View Article and Find Full Text PDFThe search for new active substances against SARS-CoV-2 is still a central challenge after the COVID-19 pandemic. Antiviral agents to complement vaccination are an important pillar in the clinical situation. Selected cannabinoids such as cannabigerol, cannabicyclol, cannabichromene, and cannabicitran from and synthetic homologues of cannabigerol and cannabicyclol were evaluated for effects on the cell viability of Vero cells (CC of cannabigerol and cannabicyclol 40 resp.
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