R-loop landscapes in the developing human brain are linked to neural differentiation and cell-type specific transcription.

Here, we construct genome-scale maps for R-loops, three-stranded nucleic acid structures comprised of a DNA/RNA hybrid and a displaced single strand of DNA, in the proliferative and differentiated zones of the human prenatal brain. We show that R-loops are abundant in the progenitor-rich germinal matrix, with preferential formation at promoters slated for upregulated expression at later stages of differentiation, including numerous neurodevelopmental risk genes. RNase H1-mediated contraction of the genomic R-loop space in neural progenitors shifted differentiation toward the neuronal lineage and was associated with transcriptomic alterations and defective functional and structural neuronal connectivity and .

Scalable production of large components by industrial robots and machine tools through segmentation.

The production of large components currently requires cost-intensive special machine tools with large workspaces. The corresponding process chains are usually sequential and hard to scale. Furthermore, large components are usually manufactured in small batches; consequently, the planning effort has a significant share in the manufacturing costs.

Flexible skill-based control for robot cells in manufacturing.

Decreasing batch sizes lead to an increasing demand for flexible automation systems in manufacturing industries. Robot cells are one solution for automating manufacturing tasks more flexibly. Besides the ongoing unifications in the hardware components, the controllers are still programmed application specifically and non-uniform.

HSP25 Vaccination Attenuates Atherogenesis via Upregulation of LDLR Expression, Lowering of PCSK9 Levels and Curbing of Inflammation.

[Figure: see text].

[Surgical management of acromioclavicular joint separation with transcutaneous Kirschner wire fixation. Results of follow-up in 45 patients].

45 patients were followed up who had undergone surgery because of acromioclavicular separation of the types TOSSY II and TOSSY III during 1983 to 1985. In 44 cases a fresh acromioclavicular separation had been treated via transcutaneous Kirschner wire fixation and in one case a chronic acromioclavicular separation had been treated according to the technique described by Bunnell. the anatomy of the acromioclavicular joint, the pattern of injury as well as the method of surgery with subsequent aftercare measures are described.