Publications by authors named "A Helisch"
Article Synopsis
- Radiopharmaceutical therapies (RPTs) using fibroblast activation protein (FAP) and FAP inhibitors (FAPIs) offer a new treatment option for patients with progressive metastatic cancers who have undergone multiple previous treatments.
- A study involving 6 patients with various types of metastatic solid tumors showed that fractionated Bi-FAPI-46 RPT was feasible and well tolerated, with no reported adverse effects.
- Initial results indicated mixed responses: one patient had a partial response, one had stable disease, while four experienced progressive disease, suggesting that while Bi-FAPI-46 RPT is promising, further research is needed to evaluate its effectiveness.
Unlabelled: In patients with metastasized, castration resistant prostate cancer (mCRPC) treatment with radium-223 (Xofigo) is an attractive therapeutic option. In particular, patients with high tumour load seem to profit from this treatment in regard of survival and quality of live. Aim of this study was to stratify mCRPC patients according to a quantitative imaging marker derived from routine bone scans (EXINI bone) and analyze haematopoietic toxicity of Xofigo in these patients.
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- The study focuses on the importance of genetic backgrounds in hereditary paraganglioma syndromes for effective genetic screening of patients' relatives.
- Unaffected relatives of patients with specific mutations underwent PET imaging to detect any pathological findings, with a total of 21 individuals from multiple families being analyzed.
- The results indicated that PET imaging is highly sensitive, revealing paragangliomas in most individuals with SDHD mutations, emphasizing the need for regular screenings in these patients using advanced imaging techniques.
Arteriosclerotic vascular disease is the most common cause of death and a major cause of disability in the developed world. Adverse outcomes of arteriosclerotic vascular disease are related to consequences of tissue ischemia and necrosis affecting the heart, brain, limbs, and other organs. Collateral artery growth or arteriogenesis occurs naturally and can help restore perfusion to ischemic tissues.
View Article and Find Full Text PDFAim: In somatostatin receptor-targeted therapy, renal toxicity is an expected side effect, and therefore pretherapeutic dosimetry based on a measured kinetics is preferable. In contrast, a convenient one single-time-point scan might also reveal relevant information on expected dose to organs. However, very early time points might not reflect the true retention by the renal cortex and therefore be of limited value to predict dose for the long-lived 177Lu.
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