Background: Health-related quality of life (HRQoL) can be impacted by various environmental factors: lifestyle habits, food insecurity, social-economic status, and dietary patterns. The Mediterranean diet (MedDiet) has been associated with a healthier lifestyle and better health outcomes. The aim of this study was to determine whether greater adherence to the MedDiet was associated with better HRQoL in communities with low social and economic statuses living in two social neighborhoods, "Bairro da Rosa" and "Ingote", in Portugal.
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February 2025
By-products of fruit processing may contain bioactive compounds with potential application as bioinputs. This study optimized the ultrasound-assisted extraction (UAE) of phenolic compounds from the by-products of DC (Myrtaceae) fruit to obtain bioinputs with antioxidant, antimicrobial, and antibiofilm activities. The fruit by-products (seeds and peels) were subjected to UAE optimization using the Box-Behnken design and response surface methodology.
View Article and Find Full Text PDFThe opossum has been recognized as an intermediate host for many parasites including spp., which is a protozoan that infects various mammals, including many wildlife species. A limited number of reports using serology, histopathology, and molecular assays have documented the presence of in opossums.
View Article and Find Full Text PDFDeep brain stimulation (DBS) is currently being investigated in patients and preclinical models of posttraumatic stress disorder (PTSD), but differences in behaviour according to sex remain elusive. We exposed female and male rats to fear conditioning and extinction. Thereafter, animals were treated with ventromedial prefrontal cortex DBS, followed by a battery of tests to measure fear and anxiety-like behaviour.
View Article and Find Full Text PDFER-positive/HER2-negative (ERpHER2n) breast cancer classified as PAM50 HER2-enriched (ERpHER2n-HER2E) represents a small high-risk patient subgroup. In this study, we investigate genomic, transcriptomic, and clinical features of ERpHER2n-HER2E breast tumors using two primary ERpHER2n cohorts comprising a total of 5640 patients. We show that ERpHER2n-HER2E tumors exhibit aggressive clinical features and poorer clinical outcomes compared to Luminal A and Luminal B tumors.
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