Experimental infection of chimpanzees with antihemophilic (factor VIII) materials: recovery of virus-like particles associated with non-A, non-B hepatitis.

Non-A, non-B viral hepatitis was transmitted to four colony-born chimpanzees by infusion of three lots of antihemophilic factor (factor VIII) implicated in the transmission of non-A, non-B hepatitis to two human recipients. All four inoculated animals showed histopathological evidence of viral hepatitis, and all demonstrated significant ALT elevations between seven and one-half weeks after inoculation. Acute-phase plasma from one of the infected chimpanzees (no.

Giant intrathoracic tumor masquerading as an enlarged cardiac silhouette.

This report describes a relatively asymptomatic 52-year-old man who had a markedly enlarged cardiac silhouette on chest roentgenogram when first seen. Clinical studies confirmed the presence of a mass, and thoracotomy revealed a huge intrathoracic tumor. The lesion was interpreted as an intrapulmonary hamartoma that had undergone malignant degeneration.