Risk of T lesions when discontinuing fingolimod: a nationwide predictive and comparative study.

Fingolimod is a frequently used disease-modifying therapy in relapsing-remitting multiple sclerosis. However, case reports and small observational studies indicate a highly increased risk of disease reactivation after discontinuation. We aimed to investigate the risk of radiological disease reactivation in patients discontinuing fingolimod.

Real-world experience of cladribine treatment in relapsing-remitting multiple sclerosis: A Danish nationwide study.

Background: Cladribine is a nucleoside analogue interfering with synthesis and repair of DNA. Treatment with cladribine leads to a preferential reduction in lymphocytes, resulting in profound depletion of B-cells with a rapid recovery of naïve B-cells, while T-cell show a lesser but long-lasting depletion It is approved for treatment of relapsing multiple sclerosis (MS). Cladribine tablets 3.

[Terminal phase hydration, pain and delirium].

Hydration of the terminal patient may relieve confusion and complaints of "dry mouth". But it may worsen oedema of the brain, lungs, and extremities, worsen terminal rattling and cause a need for frequent changing of diapers. The decision of whether and how to treat a dying patient with fluids should therefore be an integral part of the terminal treatment plan.

Chlamydia pneumoniae-associated ADEM.

Inflammatory demyelinating diseases are a common cause of neurologic disability in young adults, and usually the cause is unknown. We describe a case of acute disseminated encephalomyelitis (ADEM) associated with Chlamydia pneumoniae infection. An 18-year-old previously healthy women, with a one-week history of coryzal illness, was admitted because of progressive headache, dizziness, and a left-sided hemiparesis.

[Diabolic hiccup].

Hiccup is a brief involuntary inspiratory movement followed by glottal closure. Transitory hiccup is usually caused by epigastric irritation. Rarely, hiccup may last for a long time, and is known as diabolic hiccup.