Publications by authors named "A Hedayatizadeh-Omran"
Article Synopsis
- Prostate cancer, a common cancer in men, is influenced by various factors including age, genetics, and lifestyle, with mutations in the TP53 gene linked to poor patient outcomes.
- Research shows that men with TP53 mutations have significantly lower overall survival rates and faster disease progression compared to those without these mutations.
- Monitoring TP53 mutations is important in managing prostate cancer treatment, as they indicate a higher risk of death and disease progression.
Article Synopsis
- Anemia is a significant public health issue, contributing to high rates of illness and death, prompting a study on its prevalence and related factors in the Tabari cohort population.
- The study involved over 10,000 participants, revealing that 13.4% were diagnosed with anemia, with factors such as gender, urban residence, social economic status, and drug abuse affecting the likelihood of being anemic.
- The findings indicate a higher odds of anemia for females, urban dwellers, and individuals with poor socioeconomic conditions, alongside various health indicators such as BMI and cholesterol levels.
Article Synopsis
- The study investigated the combined occurrence of diabetes mellitus (DM) and thyroid dysfunction (TD) in a population of adults aged 35-70 in Iran, with a significant percentage of participants included.
- The prevalence of thyroid dysfunction among those with Type 2 diabetes was found to be 13.2%, while the prevalence of Type 2 diabetes in those with thyroid dysfunction was 9.2%.
- Key risk factors for this comorbidity included being female, older age, smoking, higher waist circumference, low HDL cholesterol, and low physical activity levels.
Background And Objective: Globally, Gastric Cancer (GC) ranks as the fifth leading cause of cancer-related deaths. GC is a multifaceted malignancy with diverse etiologies; however, understanding the shared molecular mechanisms can aid in discovering novel targeted therapies for GC. This study has employed a drug repositioning approach to explore new drug candidates for treating GC.
View Article and Find Full Text PDFChemotherapeutic agents often lack specificity, intratumoral accumulation, and face drug resistance. Targeted drug delivery systems based on nanoparticles (NPs) mitigate these issues. Poly (lactic-co-glycolic acid) (PLGA) is a well-studied polymer, commonly modified with aptamers (Apts) for cancer diagnosis and therapy.
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