Publications by authors named "A Hebda"
The accurate diagnosis of brain tumour is very important in modern neuro-oncology medicine. Magnetic resonance spectroscopy (MRS) is supposed to be a promising tool for detecting cancerous lesions. However, the interpretation of MRS data is complicated by the fact that not all cancerous lesions exhibit elevated choline (Cho) levels.
View Article and Find Full Text PDFIntroduction: This study focuses on the challenge of distinguishing between tumour recurrence and radiation necrosis in glioma treatment using magnetic resonance imaging (MRI). Currently, accurate differentiation is possible only through surgical biopsy, which is invasive and may cause additional damage. The study explores non-invasive methods using dynamic susceptibility contrast (DSC) MR perfusion with parameters like relative peak height (rPH) and relative percentage of signal-intensity recovery (rPSR).
View Article and Find Full Text PDFCirculating tumor HPV DNA (ctHPV16) assessed in liquid biopsy may be used as a marker of cancer in patients with HPV-associated oropharyngeal cancer (HPV + OPC). Factors influencing the initial ctHPV16 quantity are not well recognized. In this study we aimed to establish what factors are related to the level of ctHPV16 at the time of diagnosis.
View Article and Find Full Text PDFPurpose: The purpose of this work was to establish a database of tissue sodium concentration (TSC) in the normal brain of healthy volunteers. Tissue sodium concentration can be used as a sensitive marker of tissue viability in stroke or radiation therapy monitoring.
Material And Methods: Thirty-seven volunteers were scanned with a Na protocol in the span of one year; within this group, 29 studies were of acceptable quality.
Article Synopsis
- H-magnetic resonance spectroscopy (H-MRS) is a non-invasive method for studying tissue metabolism, but its application in spinal cord examinations has been limited due to technical challenges.
- A H-MRS protocol was established with healthy volunteers, resulting in the acquisition of 48 spectra from different regions of the spinal cord, revealing the difficulty of working with smaller voxel sizes compared to brain exams.
- About 60% of the spectra obtained were of acceptable quality, suggesting that despite challenges, H-MRS can enhance diagnostic information for intramedullary lesions in the spinal cord.