Publications by authors named "A Hawley"
Article Synopsis
- The case discusses a kayaker who experienced severe accidental hypothermia after a 50-minute immersion in 3°C water, managing to remain conscious and shivering despite a low core temperature of 22.9°C.
- Typically, severe hypothermia results in unconsciousness and the absence of shivering, but this patient’s experience challenges those expectations.
- The findings suggest that rapid, minimally invasive rewarming is possible even in severely hypothermic individuals who show signs of consciousness and shivering, emphasizing the need for a comprehensive assessment rather than strict adherence to hypothermia classification systems.
Skeletal muscle plays a critical role throughout the aging process. People living with sarcopenia, a progressive and generalized loss of skeletal muscle mass and function, often experience diminished quality of life, which can be attributed to a long period of decline and disability. Therefore, it is important to identify modifiable factors that preserve skeletal muscle and promote successful aging (SA).
View Article and Find Full Text PDFThe development of formulation approaches to coadminister lopinavir and ritonavir antiretroviral drugs to children is necessary to ensure optimal treatment of human immunodeficiency virus (HIV) infection. It was previously shown that milk-based lipid formulations show promise as vehicles to deliver antimalarial drugs by enhancing their solubilization during the digestion of the milk lipids under intestinal conditions. In this study, we investigate the role of digestion of milk and infant formula on the solubilization behavior of lopinavir and ritonavir to understand the fate of drugs in the gastrointestinal (GI) tract after oral administration.
View Article and Find Full Text PDFArticle Synopsis
- Individuals with mild cognitive impairment (MCI) who carry the APOE4 allele show higher levels of muscle ApoE and plasma pTau181, which are linked to cognitive decline and may indicate stress in skeletal muscle.
- The study revealed that Hsp72, a protective protein, negatively correlates with mitochondrial respiration rates in these individuals, suggesting that cellular stress influences muscle function.
- Overall, findings highlight a connection between metabolic health in skeletal muscle and cognitive abilities in older adults carrying the APOE4 allele, reinforcing the potential role of mitochondrial dysfunction in Alzheimer's disease progression.